Compound Screening
Application of SURFE²R technology for examination of the effect of compounds on the activity of transporters
At present, IonGate offers SURFE²R-based, in-house services for secondary screening and compound profiling. Investigation of the effects of compounds on selected targets, including rank order and IC50 determination is provided. Reversibility of compound action can easily be tested.
To date, more than 40 transporters can be investigated with SURFE2R™ Technology covering, amongst others, the relevant drug targets of key indication areas, such as heart and circulation diseases, cancer, CNS- and metabolism-related disorders. The following assays are routinely available:
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NaviSURF™ Assay Mitochondria:
- ADP/ATP Carrier (ANT)
- ATP Synthesis
- Complex I and III
- Complex II and III
- Complex IV
- Respiratory chain and uncoupling
- NaviSURF Assay NaK-ATPase, sodium/potassium ATPase
- NaviSURF Assay NCX1, sodium/calcium exchanger
- NaviSURF Assay rbSGLT1, sodium/glucose transporter
- NaviSURF Assay HK-ATPase, gastric proton pump
- NaviSURF Assay PepT1, proton/peptide transporter
- NaviSURF Assay PAT1, proton/amino acid transporter
- NaviSURF Assay EAAC1, neuronal glutamate transporter
- NaviSURF Assay CNT1, concentrative nucleoside transporter
- NaviSURF Assay rOCT2, organic cation transporter
In addition, IonGate offers customers the opportunity to tailor applications according to their specific requirements, targets and sample material.
The comprehensive technology and support provided by IonGate ensures that customers can venture into the new territory of transporter-related drug discovery with total confidence.
